Searchable abstracts of presentations at key conferences in endocrinology

ea0031p147 | Growth and development | SFEBES2013

Effects of the endocrine disrupting herbicide, Atrazine, on pituitary development, gene expression and signalling pathways in Zebrafish (Danio rerio) and mouse pituitary cell lines

Swain Joshua , Lessey Andrew , Mirczuk Samantha , Lambertucci-Bonnet Julien , Tucker Lisa , McGonnell Imelda , Fowkes Robert

Atrazine (ATR) is a widely used herbicide, with known effects as an endocrine disrupting chemical. Several studies have implicated ATR in causing disorders of sex development in reptiles, and chronic exposure can cause an increase incidence of intersex in fish, suggesting that the hypothalamo-pituitary–gonadal axis is a major site of ATR action. In this study, we investigated whether acute exposure (hours to days) to ATR could cause abnormalities in the development of Zeb...